Mendelian randomization study of height and risk of colorectal cancer
Identifieur interne : 002B46 ( Main/Exploration ); précédent : 002B45; suivant : 002B47Mendelian randomization study of height and risk of colorectal cancer
Auteurs : Aaron P. Thrift [États-Unis] ; Jian Gong [États-Unis] ; Ulrike Peters [États-Unis] ; Jenny Chang-Claude [Allemagne] ; Anja Rudolph [Allemagne] ; Martha L. Slattery [États-Unis] ; Andrew T. Chan [États-Unis] ; Tonu Esko [Estonie, États-Unis] ; Andrew R. Wood [Royaume-Uni] ; Jian Yang [Australie, Danemark] ; Sailaja Vedantam [États-Unis] ; Stefan Gustafsson [Suède] ; Tune H. Pers [États-Unis] ; John A. Baron [États-Unis] ; Stéphane Bezieau [France] ; Sébastien Küry [France] ; Shuji Ogino [États-Unis] ; Sonja I. Berndt [États-Unis] ; Graham Casey [États-Unis] ; Robert W. Haile [États-Unis] ; Mengmeng Du [États-Unis] ; Tabitha A. Harrison [États-Unis] ; Mark Thornquist [États-Unis] ; David J. Duggan [États-Unis] ; Loic Le Marchand [États-Unis] ; Mathieu Lemire [Canada] ; Noralane M. Lindor [États-Unis] ; Daniela Seminara [États-Unis] ; Mingyang Song [États-Unis] ; Stephen N. Thibodeau [États-Unis] ; Michelle Cotterchio [Canada] ; Aung Ko Win [Australie] ; Mark A. Jenkins [Australie] ; John L. Hopper [Australie] ; Cornelia M. Ulrich [États-Unis] ; John D. Potter [États-Unis, Nouvelle-Zélande] ; Polly A. Newcomb [États-Unis] ; Robert E. Schoen [États-Unis] ; Michael Hoffmeister [Allemagne] ; Hermann Brenner [Allemagne] ; Emily White [États-Unis] ; Li Hsu [États-Unis] ; Peter T. Campbell [États-Unis]Source :
- International Journal of Epidemiology [ 0300-5771 ] ; 2015.
Descripteurs français
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English descriptors
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Abstract
Url:
DOI: 10.1093/ije/dyv082
PubMed: 25997436
PubMed Central: 4481609
Affiliations:
- Allemagne, Australie, Canada, Danemark, Estonie, France, Nouvelle-Zélande, Royaume-Uni, Suède, États-Unis
- Arizona, Bade-Wurtemberg, Californie, Caroline du Nord, District de Karlsruhe, East Middle Sweden, Géorgie (États-Unis), Hawaï, Maryland, Massachusetts, Minnesota, Pays de la Loire, Pennsylvanie, Svealand, Texas, Utah, Victoria (État), Washington (État)
- Heidelberg, Los Angeles, Melbourne, Nantes, Seattle, Uppsala
- Université d'Uppsala, Université de Californie du Sud, Université de Melbourne, Université de Washington
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Le document en format XML
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Pers</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children’s Hospital, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children’s Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Genetics, Harvard Medical School, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Broad Institute, Cambridge, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A" last="Baron">John A. 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Berndt</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W" last="Haile">Robert W. Haile</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Oncology, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Du, Mengmeng" sort="Du, Mengmeng" uniqKey="Du M" first="Mengmeng" last="Du">Mengmeng Du</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Thornquist, Mark" sort="Thornquist, Mark" uniqKey="Thornquist M" first="Mark" last="Thornquist">Mark Thornquist</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Duggan, David J" sort="Duggan, David J" uniqKey="Duggan D" first="David J" last="Duggan">David J. Duggan</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Translational Genomics Research Institute, Phoenix, AZ, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation wicri:level="1"><nlm:aff id="dyv082-AFF1">Ontario Institute for Cancer Research, Toronto, ON, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M" last="Lindor">Noralane M. Lindor</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Song, Mingyang" sort="Song, Mingyang" uniqKey="Song M" first="Mingyang" last="Song">Mingyang Song</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N" last="Thibodeau">Stephen N. Thibodeau</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Departments of Laboratory Medicine and Pathology and Laboratory Genetics, Mayo Clinic, Rochester, MN, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Laboratory Medicine and Pathology and Laboratory Genetics, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Cotterchio, Michelle" sort="Cotterchio, Michelle" uniqKey="Cotterchio M" first="Michelle" last="Cotterchio">Michelle Cotterchio</name><affiliation wicri:level="1"><nlm:aff id="dyv082-AFF1">Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Win, Aung Ko" sort="Win, Aung Ko" uniqKey="Win A" first="Aung Ko" last="Win">Aung Ko Win</name><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Ulrich, Cornelia M" sort="Ulrich, Cornelia M" uniqKey="Ulrich C" first="Cornelia M" last="Ulrich">Cornelia M. Ulrich</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Population Sciences Huntsman Cancer Institute, Salt Lake City, UT, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Population Sciences Huntsman Cancer Institute, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D" last="Potter">John D. Potter</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="dyv082-AFF1">Centre for Public Health Research, Massey University, Wellington, New Zealand,</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Centre for Public Health Research, Massey University, Wellington</wicri:regionArea><wicri:noRegion>Wellington</wicri:noRegion></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation wicri:level="3"><nlm:aff id="dyv082-AFF1">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="dyv082-AFF1">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut=" and" id="dyv082-AFF1">Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T" last="Campbell">Peter T. Campbell</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25997436</idno><idno type="pmc">4481609</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481609</idno><idno type="RBID">PMC:4481609</idno><idno type="doi">10.1093/ije/dyv082</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000193</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000193</idno><idno type="wicri:Area/Pmc/Curation">000193</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000193</idno><idno type="wicri:Area/Pmc/Checkpoint">000E66</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E66</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002E19</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E19</idno><idno type="wicri:Area/PubMed/Curation">002D43</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002D43</idno><idno type="wicri:Area/PubMed/Checkpoint">002D43</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002D43</idno><idno type="wicri:Area/Ncbi/Merge">002604</idno><idno type="wicri:Area/Ncbi/Curation">002604</idno><idno type="wicri:Area/Ncbi/Checkpoint">002604</idno><idno type="wicri:doubleKey">0300-5771:2015:Thrift A:mendelian:randomization:study</idno><idno type="wicri:Area/Main/Merge">002B46</idno><idno type="wicri:Area/Main/Curation">002B46</idno><idno type="wicri:Area/Main/Exploration">002B46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mendelian randomization study of height and risk of colorectal cancer</title><author><name sortKey="Thrift, Aaron P" sort="Thrift, Aaron P" uniqKey="Thrift A" first="Aaron P" last="Thrift">Aaron P. Thrift</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:aff id="dyv082-AFF1">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation wicri:level="3"><nlm:aff id="dyv082-AFF1">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Esko, Tonu" sort="Esko, Tonu" uniqKey="Esko T" first="Tonu" last="Esko">Tonu Esko</name><affiliation wicri:level="1"><nlm:aff id="dyv082-AFF1">Estonian Genome Center, University of Tartu, Tartu, Estonia,</nlm:aff><country xml:lang="fr">Estonie</country><wicri:regionArea>Estonian Genome Center, University of Tartu, Tartu</wicri:regionArea><wicri:noRegion>Tartu</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children’s Hospital, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children’s Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Genetics, Harvard Medical School, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Broad Institute, Cambridge, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Wood, Andrew R" sort="Wood, Andrew R" uniqKey="Wood A" first="Andrew R" last="Wood">Andrew R. Wood</name><affiliation wicri:level="1"><nlm:aff id="dyv082-AFF1">Genetics of Complex Traits, University of Exeter Medical School, Exeter, UK,</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Genetics of Complex Traits, University of Exeter Medical School, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name><affiliation wicri:level="1"><nlm:aff id="dyv082-AFF1">Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Brain Institute, University of Queensland, Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="dyv082-AFF1">University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD, Australia,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Translation Research Institute, Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="dyv082-AFF1">Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark,</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby</wicri:regionArea><wicri:noRegion>Lyngby</wicri:noRegion></affiliation></author><author><name sortKey="Vedantam, Sailaja" sort="Vedantam, Sailaja" uniqKey="Vedantam S" first="Sailaja" last="Vedantam">Sailaja Vedantam</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children’s Hospital, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children’s Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Broad Institute, Cambridge, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Department of Medical Sciences, Uppsala University, Uppsala, Sweden,</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Sciences, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Pers, Tune H" sort="Pers, Tune H" uniqKey="Pers T" first="Tune H" last="Pers">Tune H. Pers</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children’s Hospital, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Divisions of Endocrinology and Genetics and Center for Basic Translational Obesity Research, Boston Children’s Hospital, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Genetics, Harvard Medical School, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Broad Institute, Cambridge, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A" last="Baron">John A. Baron</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stéphane" last="Bezieau">Stéphane Bezieau</name><affiliation wicri:level="3"><nlm:aff id="dyv082-AFF1">CHU Nantes, Service de Génétique Médicale, Nantes, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation wicri:level="3"><nlm:aff id="dyv082-AFF1">CHU Nantes, Service de Génétique Médicale, Nantes, France,</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHU Nantes, Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W" last="Haile">Robert W. Haile</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Division of Oncology, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Du, Mengmeng" sort="Du, Mengmeng" uniqKey="Du M" first="Mengmeng" last="Du">Mengmeng Du</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Thornquist, Mark" sort="Thornquist, Mark" uniqKey="Thornquist M" first="Mark" last="Thornquist">Mark Thornquist</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Duggan, David J" sort="Duggan, David J" uniqKey="Duggan D" first="David J" last="Duggan">David J. Duggan</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Translational Genomics Research Institute, Phoenix, AZ, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Lemire, Mathieu" sort="Lemire, Mathieu" uniqKey="Lemire M" first="Mathieu" last="Lemire">Mathieu Lemire</name><affiliation wicri:level="1"><nlm:aff id="dyv082-AFF1">Ontario Institute for Cancer Research, Toronto, ON, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Institute for Cancer Research, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Lindor, Noralane M" sort="Lindor, Noralane M" uniqKey="Lindor N" first="Noralane M" last="Lindor">Noralane M. Lindor</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Song, Mingyang" sort="Song, Mingyang" uniqKey="Song M" first="Mingyang" last="Song">Mingyang Song</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N" last="Thibodeau">Stephen N. Thibodeau</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Departments of Laboratory Medicine and Pathology and Laboratory Genetics, Mayo Clinic, Rochester, MN, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Laboratory Medicine and Pathology and Laboratory Genetics, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Cotterchio, Michelle" sort="Cotterchio, Michelle" uniqKey="Cotterchio M" first="Michelle" last="Cotterchio">Michelle Cotterchio</name><affiliation wicri:level="1"><nlm:aff id="dyv082-AFF1">Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada,</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Win, Aung Ko" sort="Win, Aung Ko" uniqKey="Win A" first="Aung Ko" last="Win">Aung Ko Win</name><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Melbourne School of Population Health, University of Melbourne, Melbourne, VIC, Australia,</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Ulrich, Cornelia M" sort="Ulrich, Cornelia M" uniqKey="Ulrich C" first="Cornelia M" last="Ulrich">Cornelia M. Ulrich</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Population Sciences Huntsman Cancer Institute, Salt Lake City, UT, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Population Sciences Huntsman Cancer Institute, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D" last="Potter">John D. Potter</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="dyv082-AFF1">Centre for Public Health Research, Massey University, Wellington, New Zealand,</nlm:aff><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Centre for Public Health Research, Massey University, Wellington</wicri:regionArea><wicri:noRegion>Wellington</wicri:noRegion></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Department of Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation wicri:level="3"><nlm:aff id="dyv082-AFF1">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="dyv082-AFF1">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany,</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="dyv082-AFF1">Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff wicri:cut=" and" id="dyv082-AFF1">Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T" last="Campbell">Peter T. Campbell</name><affiliation wicri:level="2"><nlm:aff id="dyv082-AFF1">Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">International Journal of Epidemiology</title><idno type="ISSN">0300-5771</idno><idno type="eISSN">1464-3685</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Body Height (genetics)</term><term>Case-Control Studies</term><term>Colonic Neoplasms (genetics)</term><term>Female</term><term>Humans</term><term>Male</term><term>Mendelian Randomization Analysis</term><term>Middle Aged</term><term>Rectal Neoplasms (genetics)</term><term>Risk Factors</term><term>Sex Distribution</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de randomisation mendélienne</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Répartition par sexe</term><term>Sujet âgé</term><term>Taille (génétique)</term><term>Tumeurs du côlon (génétique)</term><term>Tumeurs du rectum (génétique)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Body Height</term><term>Colonic Neoplasms</term><term>Rectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Taille</term><term>Tumeurs du côlon</term><term>Tumeurs du rectum</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Mendelian Randomization Analysis</term><term>Middle Aged</term><term>Risk Factors</term><term>Sex Distribution</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de randomisation mendélienne</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Répartition par sexe</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> For men and women, taller height is associated with increased risk of all cancers combined. For colorectal cancer (CRC), it is unclear whether the differential association of height by sex is real or is due to confounding or bias inherent in observational studies. We performed a Mendelian randomization study to examine the association between height and CRC risk.</p><p><bold>Methods:</bold> To minimize confounding and bias, we derived a weighted genetic risk score predicting height (using 696 genetic variants associated with height) in 10 226 CRC cases and 10 286 controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for associations between height, genetically predicted height and CRC.</p><p><bold>Results:</bold> Using conventional methods, increased height (per 10-cm increment) was associated with increased CRC risk (OR = 1.08, 95% CI = 1.02–1.15). In sex-specific analyses, height was associated with CRC risk for women (OR = 1.15, 95% CI = 1.05–1.26), but not men (OR = 0.98, 95% CI = 0.92–1.05). Consistent with these results, carrying greater numbers of (weighted) height-increasing alleles (per 1-unit increase) was associated with higher CRC risk for women and men combined (OR = 1.07, 95% CI = 1.01–1.14) and for women (OR = 1.09, 95% CI = 1.01–1.19). There was weaker evidence of an association for men (OR = 1.05, 95% CI = 0.96–1.15).</p><p><bold>Conclusion:</bold> We provide evidence for a causal association between height and CRC for women. The CRC-height association for men remains unclear and warrants further investigation in other large studies.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Danemark</li><li>Estonie</li><li>France</li><li>Nouvelle-Zélande</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Arizona</li><li>Bade-Wurtemberg</li><li>Californie</li><li>Caroline du Nord</li><li>District de Karlsruhe</li><li>East Middle Sweden</li><li>Géorgie (États-Unis)</li><li>Hawaï</li><li>Maryland</li><li>Massachusetts</li><li>Minnesota</li><li>Pays de la Loire</li><li>Pennsylvanie</li><li>Svealand</li><li>Texas</li><li>Utah</li><li>Victoria (État)</li><li>Washington (État)</li></region><settlement><li>Heidelberg</li><li>Los Angeles</li><li>Melbourne</li><li>Nantes</li><li>Seattle</li><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li><li>Université de Californie du Sud</li><li>Université de Melbourne</li><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Thrift, Aaron P" sort="Thrift, Aaron P" uniqKey="Thrift A" first="Aaron P" last="Thrift">Aaron P. Thrift</name></region><name sortKey="Baron, John A" sort="Baron, John A" uniqKey="Baron J" first="John A" last="Baron">John A. Baron</name><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><name sortKey="Campbell, Peter T" sort="Campbell, Peter T" uniqKey="Campbell P" first="Peter T" last="Campbell">Peter T. Campbell</name><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><name sortKey="Du, Mengmeng" sort="Du, Mengmeng" uniqKey="Du M" first="Mengmeng" last="Du">Mengmeng Du</name><name sortKey="Duggan, David J" sort="Duggan, David J" uniqKey="Duggan D" first="David J" last="Duggan">David J. Duggan</name><name sortKey="Esko, Tonu" sort="Esko, Tonu" uniqKey="Esko T" first="Tonu" last="Esko">Tonu Esko</name><name sortKey="Esko, Tonu" sort="Esko, Tonu" uniqKey="Esko T" first="Tonu" last="Esko">Tonu Esko</name><name sortKey="Esko, Tonu" sort="Esko, Tonu" uniqKey="Esko T" first="Tonu" last="Esko">Tonu Esko</name><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W" last="Haile">Robert W. Haile</name><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. 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